I don't think "dueling" will be the same, I think Blizzard will implement some sort of PvP server or a dueling arena.
Hell no it will be horrible to have to leave a game when doing quest i always liked it when you could just have a match outside of town.. it should be kept the same way but they should also add Some sort of Server with a Map specially for PVP / Guild PVP that can hold more than 8 people.
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Quote from name=" Diablo 3"s Lead Designer Jay Wilson" »
We're trying to balance satisfying the fans and also creating a game that feels like our own.
Dueling was a key feature of the game's success, I believe, since it was based on the instant-gratification philosophy that made the game critical to any time-limited player. It will probably be limited to certain types of games or (a) completely different server(s), though, because of the problems we've had with level 90's pking level 11's in Act running games.
a pvp realm or server will do good (maybe a couple of those)
or a pvp arena
or an duel invitation system, which means u cannot attack another player unless yu've been invited or has invited someone and they have accepted