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Quote from Deviant

I was stuck same as OP on Ghom till I gave up and decided to tank him. I used

Grenades / Gas Grenades

Chakram / Shuriken Cloud

Shadow Power / Gloom (although I never had to use it during the fight)

Caltrops / Jagged Spikes

Sentry / Guardian Turret

Preparation / Backup Plan (didn't need to use this one during the fight either)

Passives: Custom Engineering, Numbing Traps, Cull the Weak (You can switch the last one with Night Stalker for more Gloom uptime);

My gear is far from being the best.For the fight I just switched out my bow and quiver for a handbow + shield. When I did the kill I had around 1300 life on hit, 35k life, 4k armor and around 550 all res.All the tactics you need is stay in his face in one spot and re-apply your Caltrops..

Quote from ZcyTeck

I'm sitting on an old computer, and it stalls when entering heavily graphical sites (such as battle.net).. so, no links, sorry. Anyway, I'm below 10 post, so that wouldn't be possible.

How I did it.

~300 Poisonresist; 200 allresist (physical etc.).
~25-30k hp. (Life% helps alot vs. pure Vita)
2x 1h Crosbow with ~7-800 Life On Hit EACH. (Dual Wield)
(Ignore weapon dps. I used 487 and 502 dps(!)). Cheap weapons for about 50k each; one had Int, the other had vitality)

Enchantress follower (with charm/armor/pool of purple stuff/attackspeed).

Keys:
1: Caltrops (any version. I started with tortorus ground the first time; and are currently using the last in the line (cant remember name right now, but gives +10crit for standing in the trap)).
2: Shadow Power (gloom).
3: Preperation (...The one that slowly ticks your dicipline back up).
4: Sentry Turret (Guardian Turret).
M1: Grenades (Gas Grenades).
M2: Any. Chakrams (shuriken) / Ele arrow... Doesnt really matter. You won't be using it.

Custom Engineering; Nightstalker(random of your choice); Numbing Traps.

Run in his face and place yourself just next to the coloumn on the right side. Place your turret and a Caltrop. Target him and start casting grenades. His first few hits will hit you very hard, so be ready with Shadow Power.

Keep counting to yourself to 3, then place a new caltrop. Over and over. Only use grenades. You'll likely hear your DH saying "I need healing" -cryouts, but don't worry.
When his blobs spawn, your Life on Hit will gain the bonus from both Ghom and blobs.
- I personally tried with Stun Grenades in this fight, also later on with higher LoH and Resist... Didn't work. Only Gas grenades. (I assume the ticks from Gas works with LoH).

You can easily feel if you've forgotten to place the caltrops. At some point during the fight, you'll need to replace the turret... Do so, if you feel you have enough dicipline for it; else pop the preperation and use it there.

*Edit: With your stats... Just get two 1h crosbows and the above talents... You should be fine this way)*

--- This is how I did it. I had 0 NV buffs the first time, as I ... Like you, just hit a wall and tried almost everything.
Oddly enough, this works. Low resist, but somewhat higher life-pool than normally; ~8k dps(!); ~1700 Life On Hit.

Hope you'll try this.