Wherever that Black Soulstone fell, by now it has surely corrupted at least ONE person, so going off that idea we could easily be looking at an expansion with lots of new NPCs. I'm guess Adria will be back, since from day one people have been asking what happened to her at D3's end.
For a new character class, I'm only going to speculate something with Strength as its main stat. The other stats are shared by two classes each already, so it makes the most sense to add either another Strength class or another main stat to the game, and I seriously doubt the latter is happening.
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i would choose my own religion and worship my own spirit, but if he ever preached to me i wouldn't want to hear it. i'd drop him, a forgotten god, languishing in shame; and then if i hit stormy seas, i'd have myself to blame.