Magic Missile is a singletarget spell while Arcane Orb is an AoE. A damage-focused Magic Missile rune hits hard enough to outweigh the AP generation on a singletarget - that's good! If it didn't, it would never be a viable choice for anyone.
However, as soon as you are faced with more than one enemy, being able to cast additional Arcane Orbs vastly outweighs the extra singletarget damage from crimson MM. Or you could socket multi-MM or piercing-MM and increase your AoE power that way.
I think it's good that different runes are better in different scenarios. Life would be pretty boring if one rune was clearly superior to all the others!
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However, as soon as you are faced with more than one enemy, being able to cast additional Arcane Orbs vastly outweighs the extra singletarget damage from crimson MM. Or you could socket multi-MM or piercing-MM and increase your AoE power that way.
I think it's good that different runes are better in different scenarios. Life would be pretty boring if one rune was clearly superior to all the others!