One skill that would definitely be broken to have all runes active on is pretty much any of the large cool down buff skills (Akarat's Champion, Vengance, Wrath of The Berserker, Archon, ect.) because those skills are already considered OP with only one or 2 runes active (depending on gear) the only way blizzard could balance that power with only one or two was with a massive cool down (which most builds have a way to negate) so being able to have all runes active would be so broken OP that it wouldn't even be funny.
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One skill that would definitely be broken to have all runes active on is pretty much any of the large cool down buff skills (Akarat's Champion, Vengance, Wrath of The Berserker, Archon, ect.) because those skills are already considered OP with only one or 2 runes active (depending on gear) the only way blizzard could balance that power with only one or two was with a massive cool down (which most builds have a way to negate) so being able to have all runes active would be so broken OP that it wouldn't even be funny.