This is my end game (hell and inferno) pve build for D3. This spec has a combination of powerful aoe abilities that have been runed to make them equally effective as single target damage. The rune for overpower, when combined with Ignore Pain and the Relentless passive skill makes this spec very durable against instant high burst incoming damage, and is complemented with the Pound of Flesh passive. The Ruthlessness passive makes this spec even more effective, because it goes hand in hand with the Hammer of the Ancients and Overpower abilities. All in all, this spec is about dealing very high potential damage while enabling a high chance to survive powerful burst damage from enemies.
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http://us.battle.net/d3/en/calculator/barbarian#bZdUiP!aZU!YZYaZZ