Natalya says here purpose was to watch Ormus and make sure he didn't succumb to Mephisto's power.
When you kill him, there is obviously no more Mephisto to corrupt Ormus, thus Natalya no longer needs to watch him so she leave to go on here next assignment and keep an eye o nthe next mage on here list.
She is an assassin, they hunt down corrupt mages.
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-Humankind cannot gain anything without first giving something in return. To obtain, something of equal value must be lost. That is alchemy's First Law of Equivalent Exchange. In those days, we really believed that to be the world's one, and only, truth.
How do you plan to have the story flow nicely along and appeal to old Diablo 2 fans even though Diablo 3 takes place 20 years after the events of LoD?
Edit: Big fail, no sound but i can see everything.
Edit2: Or... Whos the girl in the Cinematics? Does she play a big role in your quest to stop hell for good?