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Quote from Bagstone

Exactly what Jamoose said. If you just enter some numbers in the calculator I wrote (yes, specifically for this purpose) it will show you that keeping numbers on par is better.

You can't put a number on it though. 75% doesn't mean anything. Go as high as you want. My monk is at 98% combined damage reduction, many wizards go for > 95% combined damage reduction, but there are also glass canons with less than 70% on each single damage reduction. Whatever works for you, but the higher the better because on Torment 6 every single percent reduction counts.