First of all roll Grenade damage into belt and pants. That's +30% dmg that is not additive to anything.
Second of all, you're missing quite a lot of Crit Damage (Rose, poor amu, bad roll on CoE).
All in all you're missing over 100% CD
Also put Calamity to your right hand. Unless they changed it, the damage comes from character's right hand.
Finally - start investing in Caldeon's. Even 70-80's give you huge boost.
Would be nice to see a video. A lot of mistakes come from bad gamplay. Like focusing too much on trash, not skipping bad elites. Etc