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Active Combo * # of Runes * Passive Combo = number of potential builds
Barbarian (22c6)*5 * (15c3) = (74,913)*5 * 455 = 170,427,075
Demon Hunter (23c6)*5 * (13c3) = (100,947)*5 * 286 = 144,354,210
Monk (21c6)*5 * (13c3) = (54,264)*5 * 286 = 77,597,520
Witch Doctor (22c6)*5 * (12c3) = (74,613)*5 * 220 = 82,074,300
Wizard (25c6)*5 * (12c3) = (177,100)*5 * 220 = 194,810,000
Total = 669,263,105 different possible builds
(803,115,726 if including un-runed skills)
Happy for my maths to be ripped apart