As I progressed through act V I had this feeling that more of the focus was pointed at us, the Nephalem. How strong we were, how we were special. Of course it wasn't pushed completely aside, anyone who has completed act V by now will have noticed that Malthael was still the main villain at hand and needed to be dealt with.
The ending cinematic after the death of Malthael gave me chills because it wasn't until then that I realised the emphasis that the characters of the campaign had put on our ever evolving power and ability to overcome all odds. What Tyrael said could have very well been a hint at what's to come. "But within him/her beats a mortal heart that will one day be tempted to corruption. On that day, will he/she have the strength to resist, or will he/she be our doom."
Sure Diablo has been released from the soulstone and will resurrect one again, but I strongly feel that we will become the threat in the next expansion, if there is one.
Bashiok - Blizzard Representative - 08/01/2011 -"So how many skill combinations are there now? Well taking into account 6 active skills, all the rune combinations, and 3 passives we currently expect each class to have roughly 2,285,814,795,264 different build combinations."
"Hey, I thought you'd like the witty irony of grub-on-glowie violence!"