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- Download and install Radeonpro
- Setup a profile for diablo 3
- Advanced > Flip Queue Size 0
- Disable aero, Force Process High priority
- ingame enable vsync
- Ingame Uncheck max foreground and background fps
Nvidia
- Nvidia control panels set Render ahead limit to 0
- ingame enable vsync
- Ingame Uncheck max foreground and background fps
*Taken from EU battle.net forums