I'm really looking forward to this, combined with the NV stacks persisting between Acts change, to inspire more variety in interesting farming routes.
This morning, I did one with my Monk...created a game just before fight with Cydaea...Keep Depths first (got 5 stacks before hitting 2nd floor, if you can believe that), Stonefort for a key run (no luck), headed down and killed Cydaea, kept going and killed Azmodan, hop skip and a jump to Iskatu, headed over for Rakanoth, and just kept going till I finished off Diablo. Isn't the best for time attack level "efficiency," but even on MP1, I gained just about an entire Paragon level. Not bad.
As for plans, I've only gotten 1 so far, for an Exalted bow, but I'd love to come up with a good Maghda-to-Kulle route, and the Oasis is in the middle, so good chance for a key run while I'm at it.
Can't wait for more plans! Folks in general chat this morning were already showing off some awesome stuff they crafted, :-)