I'm still getting my 'perfect' Witch Doctor build, though I have my preferred builds I'm still tweaking. I'm only only on level 40 so I have time to get the rest of the runes but I'm looking through the skills, do WDs have like heavy duty nuke skills like some of the other classes.. I know dire bats, acid rain and Zombears are common DDs but anything that decimate the mintions of hell?
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You pretty much named the main 3. I used splinters+toads and splinters+acid cloud with pets while leveling. Then went for Z.Bears at 60. You also need to put your favorite playstyle in the equation, because if you like standing in the mix and taking and avoiding damage, Bears is perfect, but if you like kiting and ranged better, Grasp and D.Bats are gonna be better for you. Life on hit builds usually go for Acid Cloud or Rain of Toads. You also need to make sure you have regen on your wep, helm and offhand.
I used a similar build from my 40s onward.
Dire Bats, Grasping Hands, Hex/Jinx, Soul Harvest, Spirit Walk, BBV-Rain dance - for bosses I swapped out Hex for Fetish Army unless I expected adds like with Magda.
Admittedly I was using a 600+ dps dagger (+10 mana regen) with reduced level 11 from level 49 onward so everything went quickly.
I love Bats kiting builds. For progression I prefer Hex/Jinx and for farm kiting in open areas I prefer Horrify. Hex is great in areas with invisible mobs that ambush you. Horrify is great if you are fighting melee mobs that can 2 shot you.
*EDIT* BBV - slam dance turns bats into a nuke. If you need to burn something down fast and you have the mana regen BBV- Slam Dance turns bears/Bats into hot death.