Quote from Bullsiq
Unless your gear is amazing putting Keep Depths 2 on your route is just going add rng deaths from sappers that will one shot you with unlucky explosions.
32k+ hp and you won't be oneshoted by a single explosion. Ever.
32k hp and a certain amount of resists. Even if you survive the explosion if there are quill beasts or archers around you are still probably going to die. I prefer mindless grinding with no chance of death instead of having to watch for sappers. The runbacks can be quite long of you are solo so to me it's not worth the 2-3 packs you miss out on by skipping it. It's not a right/wrong decision, rather a personal preference.