Yes and no. The Worldstone ties together all of the living things of Sanctuary because all of Sanctuary was created through it (it was stolen from the High Heavens at one point for this purpose.) Inarius then tainted it so that humans would become weak (he really just wanted them all dead), falling from their former lofty power seat of being Nephalem. It was then stopped by someone, I forget who. Now that it's destroyed, who knows what could happen to humans?