Well i had a 300 paragon wd and decided to give this a try yesterday. The spider queen adds a lot of dps to the zuni build. I was able to get from gr 45 up to 60 yesterday with no problems. Below is my thrown together build.
The amulet ess of johan (follower) and piranhado skill are a must for this, as it groups everyone together for quick dispatching the likes i have never seen before. I would spam corpse spiders, once ess of johan proc'ed i would cast piranhado they would die instantly. Fire bats worked to clean up the stragglers. The skill grave injustice made sure piranhado was almost always up.
For now that is probably as far as I can go due to missing equipment needed for higher gr. Here is a damage breakdown.
pet damage for dogs, psychopant, fetishes: 300 - 700 million
gargantuan and spider queen: 500 mil - 34 bil.
Still needs more damage, i think having a tasker and theo would really help.