Well with the way that Blizzard has been stating, there is going to be a lot of benifits with experimenting with builds. While a wizard might be exceptionally strong if using straight Fire, Frost, Lightning, or Arcane, you also have to remember monsters with immunities. In Diablo II, there was a Fallen Shaman who was immune to fire. So it probably will be best to mix and match to a certain degree, though specializing in one area with the passive skills will make killing and leveling easier.
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I have been playing Diablo and Diablo II for quite some time, and am quite looking forward to number 3. It's about time, lol.
I will try to be pretty active on this forums, and I hope to see you all in game when it releases!