...I am impressed, mortal. You have overcome the greatest challenge this world has ever faced and defeated the last of the Prime Evils.
However, we are too late to save the Worldstone. Baal's destructive touch has corrupted it completely. Given enough time, the Worldstone's energies will drain away and the barriers between the worlds will shatter. The powers of Hell will flood into this... Sanctuary... and eradicate your people and everything you've labored to build.
Therefore, I must destroy the corrupted Worldstone before the powers of Hell take root. This act will change your world forever, with consequences even I cannot foresee... However, it is the only way to ensure mankind's survival.
Go now, mortal. I have opened a portal that will lead you to safety.
May the Eternal Light shine upon you and your descendants for what you've done this day. The continued survival of mankind is your legacy. Above all else, you have earned a rest from this endless battle.
- Tyrael, Diablo 2: LoD
And yes, the fact that I know that whole dialogue off the top of my head is kinda sad
And for the sake of the lesbian touch:
Enchantress to DH "You know I sort of see you as my older sister. Is that wrong?"
DH: "No. As long as you don't expect me to give you advise on men."
Ench: "No! I would never!"
Or something among those lines x)
Or her "Should I buy new clothes, the old ones are becoming a bit too small."