The Diablocast had some really well spoken opinions on the games story. I am a massive fan of the Diablo universe and even own all the book (minus the new one) and I totally agree with what the guys say in the cast. The longer the game has sat with me, the more I see what they mean.
http://www.youtube.com/watch?v=FERvD9Q4BPo&t=70m0s starts at 1hr:10min
Another well said analysis of the games story and the way in which it was delivered to players
http://www.youtube.com/watch?v=8G4lX-MKrgI&feature=g-vrec