If you have the 2 Handed scythe - I can't remember what it is this instant - but it increases Death Nova damage by a fairly large % PER Enemy within 15 yards. You absolutely melt trash and its honestly very satisfying [to me at least].
However, using Bone Armor with that Rune is honestly suicidal. It simply costs to much health per cast - although I will say the regen benefit is very noticeable. In every attempt at a 70 Grift [I test everything here since this is what you need to unlock primal access] - That rune has gotten me killed a lot more than its helped.
The nova build I use personally is Frailty [Aura] , Death Nova [Blood Nova] , Blood Rush [Trags OP] , Devour [Cannibalize] , Bone Armor [Dislocation] , and Simulacrum [Blood and Bone]. In my cube I use Trag's Corroded Fang, Requiem Cereplate, and a CoE [My krysbin's rolled very well so I simply wear it].
Now, it's worth noting that this is definitely more a group build than a solo one. Now, you CAN solo greater rifts, but you'll quickly find yourself struggling against Rift Guardians later on down the road since this build is simply not meant to deal with them. But, for public rifts, bounties, etc...its fun, it looks badass, and it's not corpse lance.